纤维蛋白肽A检测对糖尿病肾病早期诊断的意义  

The Early Diagnosis Meaning about FPA Examination of DN

作　　者：苗晓辉 [1] 赵大力  张亚丽 [1] 

机构地区：[1]北华大学,医学院,吉林,吉林,132013 [2]长春国际旅行卫生保健中心,吉林,长春,162000

出　　处：《北华大学学报（自然科学版）》2005年第2期154-155,共2页Journal of Beihua University（Natural Science）

摘　　要：目的研究糖尿病肾病患者纤维蛋白肽A(FPA)的变化,探讨FPA的检测对早期诊断糖尿病肾病的意义.方法选择糖尿病肾病患者(DN)30例作为研究对象,糖尿病患者(DM)30例,用高效液相色谱仪检测患者尿液FPA值,将所得结果进行比较.结果 DN组与DM组、DN组与健康对照组比较,FPA水平测定中,DN组为(55.839±16.623)mg/gCr,经统计学处理,DN组与其他2组比较均有明显增高(P<0.01).结论 FPA指标检测变化非常明显,是凝血因子活化指标,能敏感的直接反映凝血过程中凝血与纤溶阶段的活化,是诊断早期糖尿病肾病的较敏感指标.ObjectiveTo explore the change of coagulation mechanism in diabetic nephropathy(DN) and to probe the early meaning about FPA examination of DN.MethodsThirty patients with diabetic nephropathy and thirty patients with diabetes as the objects of research. FPA was detected by HPLC and the results were compared to the groups.ResultsComparing DN with DM and DN with common control groups, FPA in DN was ((55.839)±(16.623))mg/gCr. Comparing DN with other two groups, they were significantly different(P<(0.01)).ConclusionThe change of FPA were very obviousy in DN, and were activate index of coagulable factor, and can directly reflect the activation of coagulation and fibrinolysis in coagulation process. It was a sensitive index of early diagnosis about DN.

关 键 词：纤维蛋白肽A 高效液相色谱仪 糖尿病肾病 

分 类 号：R967[医药卫生—药理学]