血浆降钙素原对严重烧伤患者并发感染的预测价值研究  

Prediction Value of PCT on Severe Burn Patients Accompanied by Infection Complications

作　　者：黄建宏[1] 林心[1] 欧兴义[1] 张洁[1] 黄琳[1] 

机构地区：[1]广东省珠海市人民医院,519000

出　　处：《中国全科医学》2005年第8期618-619,共2页Chinese General Practice

摘　　要：目的研究严重烧伤患者血浆降钙素原(PCT)对伤后感染并发症的辅助和鉴别诊断价值。方法应用双抗夹心免疫发光法测定50例严重烧伤患者伤后血浆PCT含量,同时用ELISA法测定血浆TNF-α、IL-6和C反应蛋白(CRP)含量,并与20例正常对照者比较,应用ROC曲线进行统计学处理。结果在严重烧伤后早期未并发感染时患者血浆TNF-α和CRP与非感染组相比差别无显著性意义(P>0.05),待并发感染后两指标在两组间的差别均有显著性意义(P<0.01),而两组患者血浆PCT和IL-6在不同的病程中差别均有显著性意义。结论在严重烧伤感染并发症的辅助诊断指标中,PCT的灵敏度较高,特异度、阳性预测值和阴性预测值也较高,是严重烧伤患者伤后感染并发症较好的预测和辅助诊断指标。Objective To study the assisting and diagnosing value of PCT in severe burn patients accompanied by infection complications.Methods TNF-α,IL 6 and CRP were measured by enzyme linked immunosorbant assay (ELISA) and PCT was determined by immunoluminometric assay (ILMA) in serial samples of plasma from 50 patients with severe burn,and compared with those of 20 normal control volunteers.Patients were divided into 2 groups (infection and non-infection groups).The differences of the above parameters between groups were compared.In addition,all data were managed by receiver operating characteristic (ROC).Results TNF-α and CRP levels in the early posttrauma period before infection were not significantly different from those in patients without infection complications,but they increased significantly following infection.However,during the whole observing period,plasma levels of PCT and IL-6 in the patients with infection complications were higher than those in patients without.Conclusion In the assisting diagnosis index,PCT has the higher sensitivity,specificity,negative and positive predictive values in diagnosing infection complication after severe burn.PCT is the better index for the prediction and assisting diagnosis of infection after severe burn.

关 键 词：严重烧伤患者 血浆降钙素原 并发感染 价值研究 双抗夹心免疫发光法 辅助诊断指标 感染并发症 血浆TNF ELISA法 IL-6 C反应蛋白 统计学处理 ROC曲线 阴性预测值 阳性预测值 PCT 显著性 诊断价值 方法应用 正常对照 患者血浆 

分 类 号：R644[医药卫生—外科学] R575.2[医药卫生—临床医学]