小鼠腹泻模型的制备与腹泻指数的应用  

An Inquiry into Preparing Diarrhea Model of Mice and Application of Diarrhea Index

作　　者：周干南[1] 胡芝华[2] 汪亚先[3] 张康宣[2] 

机构地区：[1]中国药科大学中药研究所,南京210038 [2]南京药物研究所药理室 [3]青岛市药检所

出　　处：《中草药》1994年第4期195-196,199,共3页Chinese Traditional and Herbal Drugs

摘　　要：介绍用番泻叶复制小鼠腹泻模型的规范操作。以稀便率与稀便级的乘积表示的腹泻指数作为主要观察指标，它可以全面反映个体动物的腹泻程度并具有可比性。结果表明：小鼠的腹泻指数呈正态分布；各造型组组间的腹泻指数无差异；同组小鼠连续6d造型其腹泻指数也无差异，表现出良好的重现性。该模型可推荐作为筛选抗腹泻药物使用。In Order to screen antidiarrhea drugs, the standard operation of mice diarrhea model replicated with leave of Cassia angustifolia vahl was introduced. In experiments, diarrhea index expressed with loose stool ineidence rate multiplied by loose stool grade was used as main index. It thoroughly mirrors indi. vidual diarrhea degree and possesses comparability. The result indicates that diarrhea index in mice presented normal distribution. The index between animal model groups kad no difference as well as no differcnce was found in model mice of same group for six consecutive days, with good reproduclbility. It is recommended that the model can be used for the screening of antidiarrhea drugs.

关 键 词：药理模型 腹泻 腹泻指数 

分 类 号：R285.5[医药卫生—中药学]