槐胺碱对清醒大鼠心肌急性梗塞及再灌注损伤的保护作用  

Protective Effects of Sophoramine on Acute Myocardial Infarction and Reperfusion Injury in Conscious Rats

作　　者：金英[1] 刘晓娟[1] 刘毅[1] 刘婉珠[1] 赵艳杰[1] 王晓东[2] 

机构地区：[1]锦州医学院药理教研室,121001 [2]锦州医学院附属医院胸外科

出　　处：《中草药》1994年第7期364-365,共2页Chinese Traditional and Herbal Drugs

摘　　要：用清醒大鼠冠状动脉前降支阻塞造成急性心肌梗死及再灌注损伤模型观察槐胺碱（SA）对梗塞范围及再灌注心律失常的作用。SA13．3和15mg／kg显著缩小心肌梗塞范围，降低血清LDH含量，减轻清醒大鼠缺血早期心律失常。胺碘酮7．5mg／kg有类似作用。SA13．3和15mg／kg也可显著缩短再灌注心律失常持续时间，降低室颤的发生率。The effects of sophoramine (SA) on myocardial infarction size and ischemia－induced and reperfusion－induced arrhythmia were studied in conscious rats. It was found that pretreatment with SA 13.3 and 15 mg/kg iv reduced significantly infarct size and cardiac LDH release at 6h afte left descending coronary artery ligation as compared with the control. SA 10.6, 13.3 and 15mg/kg iv decreased markedly the early ischemic arrhythmia in conscious rats. Amiodarone 7.5mg·kg－1 had the same effects on the prevention of ischemic arrhythmia. In reperfusion experiment,it decreased the incidence of ventricalar fibrillation and significantly shortened the duration of arrhythmias. These results suggest that SA has protective effects on myocardial ischemia and reperfusion injury.

关 键 词：槐胺碱 大鼠 心律失常 

分 类 号：R259.417[医药卫生—中西医结合]