50%板蓝根注射液对小鼠Friend红白血病细胞3CL-8体内外的杀伤作用  

Study on Cytotoxicity to Mouse 3CL-8 Cell of Friend Erythrocyte by 50% Dyers Woad (Isatis tinctoria) Injection in Vivo and in Vitro

作　　者：单风平[1] IonGresser 

机构地区：[1]沈阳医学院生物技术研究所,110031 [2]法国科学院肿瘤研究所,110031

出　　处：《中草药》1994年第8期417-418,共2页Chinese Traditional and Herbal Drugs

摘　　要：3CL－8细胞是小鼠受Friend病毒感染后诱导机体产生的一种永久性红细胞分化反应细胞，致病性极强。应用60％板兰根对小鼠3CL－8细胞进行体内外杀伤，结果表明：在体外细胞培养时，50％板蓝根注射液对3CL-8细胞有强大的直接杀伤作用，最低杀伤浓度可达1∶80。皮下局部注射50％板兰根时有一定的杀伤作用，3CL-8实体瘤有减少趋势。腹腔注射50％板兰根时未见对3CL－8细胞有明显的杀伤作用。The paper presented here provides evidence of cytotoxicity to mouse 3CL-8 cell of friendcrythrocyte bY 50% Isatis tinctoria injection. In vitro this extract of traditional Chinese medicine exerts a strong cytostatic effect directly on mousc 3 CL-8 cell in tissue culture at a minimum concentration of 1 ∶80 dilution. In vivo, when injected subcutaneously aud locally ontumor site, it showed some cytotoxic effect on 3 CL-8, but showed no significant cytotoxiceffect intrapertoneally.

关 键 词：小鼠 红白血病 板蓝根注射液 

分 类 号：R273.37[医药卫生—中西医结合]