天津地区汉族人维生素D受体基因多态性与Graves病的关联性研究  

Association of vitamin D receptor gene polymorphism with Graves′ disease in Tianjin area

作　　者：康东红[1] 邱明才[1] 高硕[1] 李梅[1] 高志红[1] 苏文凌[1] 

机构地区：[1]天津医科大学总医院内分泌科

出　　处：《中华内分泌代谢杂志》2005年第2期128-129,共2页Chinese Journal of Endocrinology and Metabolism

摘　　要：为探讨维生素D受体(VDR)基因多态性与Graves病(GD)的关系,以PCR-RFLP检测102名天津地区汉族正常人、120例GD患者的VDR- Bsm1、VDR -Apa1基因型、发现正常人与GD患者VDR- Bsm1、VDR- Apa1基因型、等位基因的频率差异无统计学意义。因此,VDR -Bsm1、VDR -Apa1基因型不能作为预测中国汉族人发生GD的危险性遗传标志。In order to investigate the association of vitamin D receptor (VDR) gene polymorphism with Graves′ disease, VDR-Bsm1, VDR-Apa1 genotypes were determined by PCR-RFLP in 102 healthy persons and 120 GD patients in Tianjin area. There were no differences in distributions and frequencies of VDR-Bsm1, VDR-Apa1 genotypes and alleles between healthy persons and GD patients, suggesting that the VDR-Bsm1, VDR-Apa1 genotypes seem not to be the genetic markers in predicting the risk of developing GD in Chinese people of the Han nationality.

关 键 词：天津 汉族 维生素D受体 基因多态性 GRAVES病 自身免疫性疾病 

分 类 号：R581.1[医药卫生—内分泌]