肿瘤坏死因子α对人成骨样细胞NF-κB和护骨素表达的调节  

Regulation of tumor necrosis factor-α on the expressions of nuclear factor-κB and osteoprotegerin in MG-63 cells

作　　者：向光大[1] 廖二元[1] 王运林[1] 戴如春[1] 周厚德[1] 肖新华[1] 

机构地区：[1]中南大学湘雅二医院内分泌代谢研究所

出　　处：《中华内分泌代谢杂志》2005年第2期174-175,共2页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金(39970347)

摘　　要：用肿瘤坏死因子α(TNF -α)干预培养的MG 63细胞(人成骨肉瘤来源)。结果显示:TNF -α上调MG 63细胞核蛋白p65表达,下调护骨素(OPG)mRNA和蛋白质表达。吡咯二硫氨基甲酸酯不能阻止TNF -α下调MG 63细胞OPG的作用。MG-63 cells (derived from human osteoblastoma) were treated with tumor necrosis factor-α (TNF-α). The results showed that TNF-α upregulated expression of nuclear protein p65 and downregulated expressions of OPG mRNA and protein, pyrrolidine dithiocarbamate did not abrogate the downregulation of OPG expression induced by TNF-α in MG-63 cells.

关 键 词：肿瘤坏死因子Α 人成骨样细胞 NF-ΚB 护骨素 基因表达 骨质疏松症 

分 类 号：R58[医药卫生—内分泌]