抗感染重组合异种骨的动物实验  

Animal experimental studies of anti-infective reconstituted bone xenograft

作　　者：贺利军[1] 王文涛[1] 袁志[2] 陈向阳[1] 

机构地区：[1]武警陕西总队医院外二科,陕西西安710054 [2]第四军医大学西京医院骨科,陕西西安710054

出　　处：《武警医学院学报》2005年第3期184-186,共3页Acta Academiae Medicinae CPAPF

摘　　要：【目的】检测抗感染重组合异种骨安全性。【方法】对抗感染重组合异种骨进行急性毒性试验、过敏试验、肌内埋植试验和骨内埋植试验。【结果】抗感染重组合异种骨不引起小鼠急性毒性,未引起豚鼠过敏反应,在兔骨内埋植和鼠肌内埋植未引起淋巴细胞、炎性细胞浸润。【结论】抗感染重组合异种骨可以安全、有效的试用于临床。To test safety of anti-infective reconstituted bone xenograft productsPerformed acute toxicity,hypersensitivity,intraosseous and intramusular implantation test for anti-infective reconstituted bone xenograft.Absent acute toxicity in mouse ;absent allergic reaction in guinea pig; intraosseous implant in rabbit or intramuscular implant in mouse did not lymphocyte and inflammatory cell infiltration.[Conclusion]Anti-infective reconstituted bone xenograft being used safely and validly in clinical settings.

关 键 词：抗感染重组合异种骨 安全 动物实验 

分 类 号：R687.34[医药卫生—骨科学]