利多卡因对电点燃模型的作用  

Effect of lidocaine on amygdala kindling model

作　　者：马传新[1] 岳旺[2] 

机构地区：[1]中国人民解放军第八九医院药剂科,261021 [2]青岛大学医学院药理教研室

出　　处：《中国药物与临床》2005年第4期275-277,共3页Chinese Remedies & Clinics

摘　　要：目的研究利多卡因对电点燃模型的作用。方法采用腹腔注射的给药途径,观察杏仁核点燃大鼠的行为表现,以Racine分级作为评价标准。结果利多卡因0.5～25.0mg/kg腹腔注射可依赖性抑制大鼠杏仁核点燃作用,提高阈值,降低Rcine分级(P<0.01)。利多卡因剂量>30mg/kg,有明显的兴奋作用(P<0.05)。结论利多卡因对大鼠杏仁核点燃有兴奋和抵制双重作用。Objective To investigate the effects of lidocaine on amygdala kindling models in rats. Methods The kindled rats were given lidocaine by ip injection,their behavior was evaluated by Racine staging. Results Lidocaine 5.0～25 mg/kg ip could inhibit the seizure of kindled rats,raise the threshold,reduce Recine′s stages(P<0.05);lidocaine,at a dose above 30 mg/kg,showed significant excitatory effect on kindling. Conclusion Lidocaine has both excitatory and inhibitory effects on amygdala kindling models.

关 键 词：利多卡因 点燃模型 杏仁核点燃 腹腔注射 给药途径 行为表现 评价标准 兴奋作用 双重作用 大鼠 依赖性 

分 类 号：R96[医药卫生—药理学]