中成药中违禁添加药物的液质联用仪测定研究  

Analysis of some prohibited drugs in Chinese herb extracts by HPLC/MS

作　　者：汪国权[1] 杨玉林[1] 金玉娥[1] 

机构地区：[1]上海市疾病预防控制中心理化中心实验室,上海200336

出　　处：《上海预防医学》2005年第4期153-155,共3页Shanghai Journal of Preventive Medicine

摘　　要：[目的]　建立中成药中违禁添加合成药物的筛选方法。　[方法]　采用有机溶剂提取相关的各类添加药物,用液质联用仪进行测定,并对一些一级质谱结果呈阳性的样品,进行了多级质谱结构性研究以确认化合物。　[结果]　依据各种药物的保留时间、分子离子质量、多级质谱结果等进行判断,建立了测定65种药物的筛选方法。　[结论〗　本方法建立了多种药物的质谱分析筛选分析系统,为监督和相关研究提供了技术保证。Objective] To establish a method to detect the prohibited drugs in Chinese herb extracts. [Methods] It included the extraction of drugs in organic solutions and their detection by HPLC/MS. For those positive samples their molecular structurs tested through HPLC/MS/MS. [Results] The scanning method for the identification of 65 drugs were established through their individual retention time, their special mass and buy use of HPLC/MS/MS. [Conclusion] This paper introduces an analytical system to recognize and confirm prohibited drugs in Chinese herb extracts by mass spectrum. It provides a necessary technological support for supervision and corresponding research.

关 键 词：违禁药物 液质联用仪 中成药 样品处理 

分 类 号：R288[医药卫生—中药学]