大剂量X线头部照射对雄性大鼠神经内分泌系统功能的影响  

The influence on neuroendocrine in the male rats after head irridiation with 10Gy X-rays

作　　者：刘洪宇[1] 龚守良 尉军 刘树铮 

机构地区：[1]白求恩医大一院干部病房,白求恩医大放射生物教研室

出　　处：《中风与神经疾病杂志》1994年第3期147-149,共3页Journal of Apoplexy and Nervous Diseases

摘　　要：本研究采用放射免疫分析和高效液相色谱分析等技术，观察１０ＧｙＸ线头部照射对雄性大鼠神经内分泌系统功能的影响。结果表明，头部照射后第２天，下丘脑Ｌ—Ｅｎｋ和Ｍ—Ｅｎｋ有不同程度降低，而下丘脑ＮＥ和ＤＡ明显增高，血清ＰＲＬ、ＴＳＨ和ＧＨ也有不同程度增高。提示，下丘脑具有较高的敏感性，其神经肽和神经递质所发生的变化，可直接或间接对神经内分泌系统功能产生重要影响。Abstract In the present study, RIA and HPLC were used to observe the influence of head irradiation with 10Gy X-rays on neuroendocrine in the male rats. The results showed that hypothalamic L-Enk and M-Enk contents lowered in different degrees, while hypothalamic NE nd DA contents increased obviously and serum PRL, TSH and GH levels also increased in different degrees 2 days after head irradiation. These results suggest that hypothalamus is comparatively radiosensitive and the changes of its neuropeptides and neurotransmitters may have profound influence on the function of neuroendocrine system by the direction or indirection.

关 键 词：X线 头部照射 神经肽 神经递质 

分 类 号：R816.1[医药卫生—放射医学]