山莨菪碱对急性脑微循环障碍的防治作用  

Anisodamine protection of acute cerebral microcirculation disturbance induced by high molecule weight dextran

作　　者：皮业庆[1] 尤家录 李竹亭 

机构地区：[1]湖南医科大学病理生理教研室

出　　处：《中风与神经疾病杂志》1994年第3期135-137,共3页Journal of Apoplexy and Nervous Diseases

摘　　要：本实验采用显微摄像技术观察了山莨菪碱（６５４—２）对高分子右旋糖苷（ＨＭＷＤ）诱发的大鼠急性脑微循环紊乱的防治效果。结果显示，６５４—２可明显防止ＨＭＷＤ引起的软脑膜微血管痉挛，血流减慢、淤滞甚至停灌，并能维持严重低血压状态下的脑血流。本发现为临床应用６５４—２预防、抢救缺血性脑血管疾病提供了新的实验依据。Abstract This experiment was designed to observe the protective effect of anisodamine(654-2) on acute cerebral microcirculation impairment induced by high molecule weight dextran(HMWD) in Wistar rats with an introvital microscopic-video recording system. The result showed that 654-2 significantly prevents cerebral HMWD-induced microvessels constricted, blood flow volecity slowed,sludged, and even stopped, and maintains the cerebral blood supply in severe hypotensive status. The data provide a new evidence for clinical application of 654-2 to provent or/and treat ischemic cerebrovacular diseases.

关 键 词：微循环 高分子 右旋糖苷 山莨菪碱 

分 类 号：R965[医药卫生—药理学]