新生儿高胆红素血症巨细胞病毒及胆汁酸检测的意义  

Determination and Significance of Cytomegalovirus and Total Bile Acid in Neonates with Hyperbilirubinemia

作　　者：汤鸣[1] 严越秀[1] 肖力[1] 乔萍[1] 

机构地区：[1]肇庆市第一人民医院新生儿科,肇庆526021

出　　处：《热带医学杂志》2005年第1期83-85,共3页Journal of Tropical Medicine

摘　　要：目的探讨新生儿高胆红素血症(简称高胆)时巨细胞病毒及胆汁酸检测在临床的意义。方法对208例高胆红素血症患儿和60例正常新生儿,给检测血巨细胞病毒(CMV)、谷丙转氨酶(ALT)、间接胆红素(I-BIL)、直接胆红素(D-BIL)和胆汁酸(TBA)等,并分三组进行对比观察。结果CMV阳性高胆组血ALT、D-BIL及TBA值显著高于CMV阴性高胆组(P<0.01);CMV阳性高胆组血I-BIL值与CMV阴性高胆组比较差异无显著性(P>0.05)。结论CMV感染的高胆患儿易有肝损害和胆汁淤积,对高胆患儿应检测巨细胞病毒及胆汁酸,及时了解患儿感染CMV及胆汁淤积状况,对判断病情、指导治疗和估计预后有重要意义。Objective To study the significance of clinical determination of the bile acid and cytomegalovirus to neonates with hyperbilirubinemia. Methods Blood cytomegalovirus (CMV) and alanine aminotransferase (ALT), indirect bilirubin (I BIL), direct bilirubin (D BIL) and total bile acid (TBA) were determined in 208 neonates with hyperbilirubinemia and 60 normal neonates in three groups for paired observation. Results The concentrations of blood ALT,D BIL and TBA in the hyperbilirubinemia CMV(+) group were significantly higher than that in the hyperbilirubinemia CMV(-)group (P< 0.01). The concentrations of I BIL has no significant difference between the hyperbilirubinemia CMV(+) and in tahe hyperbilirubinemia CMV(-) groups (P >0.05).Conclusion Hyperbilirubinemia and CMV infection may possibly cause damages to liver and cholestasis. Cytomegalovirus and total bile acid should be monitored in neonates with hyperbilirubinemia for prompt assessment of cytomegalovirus infection and cholestasis, which helps in judging severity of the disease, guiding therapy and evaluating the prognosis.

关 键 词：新生儿 高胆红素血症 巨细胞病毒 胆汁酸 

分 类 号：R722.13[医药卫生—儿科]