103例流行性出血热并发多器官功能障碍的临床分析  

Clinical Analysis of Epidemic Hemorrhagic Fever Induced Multiple Organs Lesion in 103 Cases with Epidemic Hemorrhagic Fever

作　　者：唐正运[1] 叶晓光[1] 廖云珍[1] 李石好[1] 

机构地区：[1]广州医学院附属第二医院感染病科,广州510260

出　　处：《热带医学杂志》2005年第2期174-175,187,共3页Journal of Tropical Medicine

摘　　要：目的了解流行性出血热病毒(EHFV)对机体的重要器官(肝、心、肾、脑、肺及胰腺)功能的影响。方法对103例流行性出血热(EHF)患者的肝、心、肾、脑、肺及胰腺等功能的检测结果进行分析。结果流行性出血热并发多器官功能障碍(MODS)的发生率为9.7%(10/103),而MODS的死亡率为70%(7/10);肝、心、肾、脑、肺及胰腺等器官功能障碍的发生率分别为86.4%、70.9%、64.1%、5.8%、4.9%及3.9%,以肝、心、肾功能障碍最常见,尤其以肝功能障碍明显;重型及危重型患者的肝、心、肾功能损害严重程度均高于轻型、中型患者(经统计学处理均有显著性或高度显者性差异)。结论EHF患者并发多器官功能损害较普遍,但以肝、心、肾功能损害最常见,尤其以肝功能障碍明显,并发MODS者死亡率高,而且病情愈重者,器官损害愈严重。Objective To investigate the changes of functions important organs including heart,liver,kidney,brain,lung and pancreas of the patie nts with epidemic hemorrhagic fever(EHF).Method A retrospective analysis on the laboratory tests of the function s of heart,liver,kidney,brain,lung and pancreas in 103cases with EHF we re carried out.Results The positive rate of the multiple org ans lesion in 103cases with epidemic hemorrhagic fever was 9.7%(10/103).The mortality of the cases with mult iple organs lesion was 70.0%(7/10).The rates of abnormal function of liver,heart,kidney,brain,lung an d pancreas were 86.4%,70.9%,64.1%,5.8%,4.9%and 3.9%respectively.The most commonly damaged organs were liver,heart and kidney.The functi onal demages of liver,heart and kidney in severe and dangerous cases were more severe than that in mild and morderate cases.There exists significant or highly significant difference statistica lly .Conclusions The functional damages of multiple o rgans are commonly observed in the cases with EHF.The most commonly dam aged organs are liver,heart and kidney.The more severe the disease is,th e more severe the lesion is.

关 键 词：流行性出血热 并发症 多器官功能障碍 

分 类 号：R373.32[医药卫生—病原生物学]