胰腺癌组织中DPC4/Smad4的表达及临床意义  

Expression and Implication of DPC4/Smad4 in Pancreatic Carcinoma

作　　者：潘小季[1] 孙维佳[1] 

机构地区：[1]中南大学湘雅医院普外科,湖南长沙410008

出　　处：《湘南学院学报（自然科学版）》2005年第1期1-3,共3页

摘　　要：目的　探讨DPC4 /Smad4在胰腺癌组织中的表达及意义。方法　采用免疫组织化学SABC法,对34例胰腺癌和慢性胰腺炎组织进行DPC4 /Smad4表达水平研究。结果　DPC4 /Smad4蛋白在胰腺癌组织中的阳性表达低于慢性胰腺炎组织(P <0 .0 5 ) ,患者性别、年龄、肿瘤大小、部位、病理分型、组织学浸润之间的表达差异无统计学意义(P >0 .0 5 )。结论　DPC4作为一种抑癌基因,其改变对胰腺癌的发生、发展可能起重要作用。Objective To explore the expression of DPC4/Smad4 in pancreatic carcinoma. Methods DPC4/Smad4 was detected in tissue sample from 34 cases with pancreatic carcinoma and 34 cases with chronic pancreatitis using SABC immunohisto-chemical methods. Tissue sample positive to DPC4/Smad4 protein was analysed statistically by SPSS10.0. Results DPC4/Smad4 was found to be significantly higher in chronic pancreatitis tissue than that in pancreatic carcinoma(P<0.05). DPC4/Smad4 was not found to have any correlation with sex, age, size and site and site of tumor ,clinical stage or pathological type. Conclusions DPC4/Smad4 may be a tumor suppressive gene, Its alteration may play an important part during tumorigenesis and development of pancreatic cancer.

关 键 词：癌组织 临床意义 SMAD4蛋白 免疫组织化学 表达差异 抑癌基因 胰腺炎 性表达 统计学 组织学 慢性 性别 肿瘤 

分 类 号：Q55[生物学—生物化学] O657.1[理学—分析化学]