蛋白负荷肾损伤早期过程中NF-κB和AT_1、AT_2的关系探讨  

The relation of NF-κB and angiotensin receptors AT_1 and AT_2 on early stage of renal lesions induced by overloading BSA

作　　者：李钊[1] 马宏[2] 李晓惠[3] 刘源[2] 

机构地区：[1]山西医科大学汾阳学院科技中心,汾阳032200 [2]山西医科大学第一临床医学院儿科 [3]北京大学医学部

出　　处：《山西医科大学学报》2005年第2期168-170,共3页Journal of Shanxi Medical University

摘　　要：目的探讨在蛋白过负荷肾病综合征幼年大鼠肾损伤过程中核因子(NF-κB)和AT1、AT2的表达及其相关性。方法4周龄Wistar大鼠单侧肾切除加腹腔注射牛血清血蛋白(BSA)造成NS模型,分别以免疫组化和原位杂交检测AT1、AT2和NFκB。结果肾病组随着病变时间的延长,NFκB和AT1、AT2表达的强度和部位均呈增强趋势(P<0.05),治疗组在相同时间点则二者都有不同程度下调(P<0.05)。结论在蛋白负荷肾病损伤过程中NFκB和AT1、AT2起着介导作用。Objective To investigate the relation of nuclear factor kappa-B and angiotensin receptors in early stage of renal tubulointerstitial lesions induced by overloading BSA. Methods Wistar male young rats of 4-week old were nephrectomized the left kidney and injected with BSA via intraperitoneal. NF-κB mRNA, AT_1 and AT_2 protein expression were detected by in situ hybridization and immunohistochemistry respectively. Results With disease aggravated NF-κB and AT_1, AT_2 expression increased markedly. While in those treated, the expression decreased at some extent. Conclusion NF-κB and AT_1, AT_2 play vital role in BSA renal lesions.

关 键 词：肾病 核因子-KB 血管紧张素转换酶抑制剂 血管紧张素受体拮抗剂 

分 类 号：R692[医药卫生—泌尿科学]