红花甙对小鼠脑缺血再灌注后记忆行为的影响  

Effects of carthamin on memory in mice after brain ischemia-reperfusion injury

作　　者：王兴文[1] 周晓红[2] 郭锐[1] 李莉[1] 彭吉霞[1] 

机构地区：[1]郧阳医学院机能学实验室,十堰442000 [2]郧阳医学院附属白浪医院

出　　处：《山西医科大学学报》2005年第2期192-194,共3页Journal of Shanxi Medical University

摘　　要：目的观察红花甙对小鼠脑缺血后记忆行为的影响。方法用昆明系小鼠夹闭双侧颈总动脉,脑缺血15min后建立再灌注模型。按组分别腹腔注射红花甙2mg·kg-1·d-1,尼莫地平2mg·kg-1·d-1及对照组生理盐水10ml·kg-1·d-1。人工常规饲养1周后,检测开场行为、回避反应和水迷宫试验以观察小鼠记忆行为的改变。结果红花甙组首次检测结果与24h后再次检测结果比较均有显著差异,而对照组则均无显著改变。红花甙组首次检测结果与24h后再次检测结果比较均有显著差异,而对照组则均无显著改变。结论结果表明脑缺血再灌注损伤可导致记忆障碍,红花甙对小鼠脑缺血后的记忆保持有较好的改善作用。Objective To observe the effects of carthamin on memory in mice after brain ischemia-reperfusion injury. Methods Kunming mouse model was developed by clamping the bilateral common carotid arteries (CCA), and after brain ischemia for 15 min the reperfusion was given. These mice were randomly divided into carthamin, nimodipine and control groups. The carthamin group was ip given carthamin 2 mg·kg^-1 ·d^-1 , nimodipine group 2 mg·kg^-1 ·d^-1 ,and control group 0.9%NS 10 ml·kg^-1 ·d^-1 .After the usual feeding for 1 week, changes of memory were observed by open field behavior, water-maze and passive avoidance response tests. Results There was significant difference between first and second tests after 24 h in carthamin group, but the control group had no change by paired tests. Conclusion The results show that cerebral ischemia-reperfusion injury may result in memory disorder and carthamin may improve it.

关 键 词：脑缺血 再灌注损伤 记忆障碍 红花甙 

分 类 号：R965[医药卫生—药理学] R364.17[医药卫生—药学]