生脉散体外对低密度脂蛋白氧化修饰的保护作用  

The Protective Effect of Chinese Medicine Recipe Shengmaisan on Oxidative Modification of Low Density Lipoprotein in Vitro

作　　者：阎道广[1] 周玫[1] 陈瑗[1] 

机构地区：[1]第一军医大学自由基医学研究室

出　　处：《中国动脉硬化杂志》1994年第4期145-148,共4页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金

摘　　要：本文以低密度脂蛋白氧化修饰为模型，以硫代巴比妥酸反应物质生成量、维生素Ｅ和荧光物质含量变化为指标，研究了生脉散对Ｃｕ２＋和Ｆｅ２＋诱导低密度脂蛋白氧化修饰的抑制作用。结果说明，生脉散能明显地抑制Ｃｕ２＋和Ｆｅ２＋诱导低密度脂蛋白氧化修饰，对这两种过渡金属诱导低密度脂蛋白氧化修饰的抑制速率和程度相似。生脉散抑制低密度脂蛋白氧化修饰的机制主要是清除脂自由基。Using the oxidative modification of low density lipoprotein(LDL) as a model and the contents of thiobabituric acid reactive substences,vitaminle E and fluorscent substances,the inhibitory effects of Shengmaisan on oxidative madification of LDL induced by Cu2+ and Fe2+ were studied.The results showed that Shengmaisan inhibited the oxidative modification of LDL significantly,and the extents of inbibition of oxidative modification of LDL induced by Cu2+ and Fe2+ were similar.The protective effect of Shengmaisan is mainly to scavenge lipid free radical.

关 键 词：生脉散 低密度脂蛋白 脂质过氧化损伤 保护作用 

分 类 号：R285.5[医药卫生—中药学]