麻风病人血液超氧化物歧化酶的研究  

Superoxide dismutase in the blood of leprous patients

作　　者：黄林邦[1] 张志渊[1] 

机构地区：[1]赣南医学院病理生理教研室,赣南医学院皮肤病理研究室

出　　处：《中国病理生理杂志》1994年第1期83-85,共3页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金

摘　　要：用亚硝酸法测定各型麻风病人（ｎ＝７３）及健康人（ｎ＝１５）血浆中ＳＯＤ总量、Ｍｎ－ＳＯＤ和Ｃｕ、Ｚｎ－ＳＯＤ含量；发现各型麻风病人血浆中ＳＯＤ总量和Ｍｎ－ＳＯＤ含量均比正常人高（Ｐ＜０．０１），而Ｃｕ、Ｚｎ－ＳＯＤ含量无显著性差异（Ｐ＞０．５）。提示麻风病人血浆中ＳＯＤ总量升高，受Ｍｎ－ＳＯＤ的影响，后者存在于细菌体内，从而证明麻风病人体内的ＳＯＤ主要来源于麻风分枝杆菌。In this study contents of total-SOD,Mn-SOD and Cu, Zn-SODof the plasma fromleprous patients (LL,BL, TT,BT,n=73)and healthy control (n=15)were measuredby the nitrous acid-method. It was shown that the contents of total-SOD and Mn-SOD ofhe plasma from all leprous patients were increased (P<0.01),but Cu,Zn-SOD were not significance(P>0.5)compared with that of the healthy control. Theresults suggested that the increaded content of total-SOD in the plasms of leprous patients was chie-fly influenced by Mn-SOD ,which was present in the bacterium.For this reason,it was confirmed that the SOD of the leprous patients in vivo was primary from the mycobacte-rium leprae itself.

关 键 词：麻风 分枝杆菌 超氧物歧化酶 

分 类 号：R755.02[医药卫生—皮肤病学与性病学]