大鼠内毒素性和败血症性休克时某些血中代谢物变化的探讨  

Changes of some metabolites in plasma of rats with endotoxic and septic shock

作　　者：邱劲[1] 郭炯[1] 甘继宏[1] 

机构地区：[1]新疆医学院病理生理教研室,新疆军区总医院心肾科

出　　处：《中国病理生理杂志》1994年第2期189-193,共5页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金

摘　　要：内毒素性和败血症性休克都有高乳酸和高氮质血症。不同的是，前者在注射内毒素后３０ｍｉｎ／血糖和动脉血压同步地进行性下降，血胰岛素水平不变，后者血糖轻度升高，血胰岛素水平降低。预先应用山莨菪硷后两型休克的高乳酸症均被有效预防，血糖变化被调整，但对高氮质血症却无影响，因为含氮物的升高是由于早期肾血管收缩所致。山莨菪硷虽能保护细胞并可因此而改善微循环，但却不能消除低动力型氧供不足，表明代谢变化不是乏氧可用所致。在内毒素休克，山莨菪硷不影响动脉血压的动态变化，未显出有扩血管效应；对静脉注入肾上腺素均有升高血糖和动脉血压的反应。败血症休克的糖耐量曲线正常。In endotoxic and septic shock, their common alterations of metabolites were he hyperlactacidemia and the hypermitraemia, the special changes in endotoxin shockwere the plasma insulin level normal and the blood glucose and arterial blood pressuredecreased synchronously; while in septic shock, blood glucose increased and plasma insulindecreased.When both cases were pretreated with anisodamine, their blood glucose werenearly regulated to normal,hyperlactacidemia were abated, and hypern it raemia were notchanged. Because the occurrence of hypernitride in plasma was owing to constriction of renalarteriole in early phase of shock; certainly,it could not be abolished by 654-2.Although,anisodamine possessed protective effect on cell by which the microcirculatory disturbancecould be improved, but it could not abate the hypoxia in hypokinetic circulatory status.Result showed that metabolic disturbance was not induced by lack of oxygen for cell toutilize. In endotoxin shock,654-2 did not influence dynamic change of arterial blood pres-sure, which showed that it possess no effect to dilatation of blood vessel.The reaction ofblood glucose to adrenalin(iv)was still existed.In septic shock glucose tolerance curvewas mormal.

关 键 词：休克 内毒素 代谢 败血症 

分 类 号：R441.9[医药卫生—诊断学]