犬失血性休克过程氧供不足与用氧障碍  

Deficient supply and inability in utilizing of oxygen in the process of hemorrhagic shock in dogs

作　　者：郭炯[1] 王建中[1] 邱劲[1] 汤文良[1] 马琪[1] 

机构地区：[1]新疆医学院病理生理教研室

出　　处：《中国病理生理杂志》1994年第2期184-188,共5页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金

摘　　要：犬在失血休克５ｈ内，ＰａＯ＿２波动上升，ＰａＣＯ＿２进行性降低。用ＰｖＯ＿２和ＰｖＣＯ＿２反映细胞用氧状态发现，在休克１ｓｔ至３ｒｄｈ在心房及诸器官有进行性ＰｖＯ＿２降低和ＰｖＣＯ＿２升高，在３ｔｄ至５ｔｈｈ二者相对恒定。此时从血氧解离曲线看，静脉氧饱和度和张力仍超过代偿极限１～２倍，代偿储备远未耗竭，氧的供求平衡是一种假象，实为细胞有用氧障碍所致。将诸器官作双因素方差分析发现肝ＰｖＯ＿２最低ＰｖＣＯ＿２最高，而肾则相反，变化反映了器官的解剖生理特点，肾ＰｖＣＯ＿２从３ｒｄｈ方急剧上升，提示开始有肾排酸保硷功能受损。在５ｈ实验全过程，动脉血ｐＨ略高于静脉血ｐＨ并平行地进行性下降，未随血气稳定而不变，说明它不是缺氧引起。In the course of 5h after hemorrhagic shock in dog, PaO_2 rose wavilywhile PaCO_2 fell progressively. Using PvO_2 and PvCO_2 as an index to reflect the O_2 utili-zation status of cell, the blood of central vein and various organic vein were tested. Theresults were as follows: PvO_2 fell and PvCO_2 rose progressively in the 1st to the 3rd hafter shock, then, within 3rd to 5th h each of them came into relatively stabilized. In themean time, the oxygen saturation and O_2 tension of venous blood Were 1 to 3 tims abovethe compensatory limit according to oxygen dissociation curve. Compensatory storage hadnot be exhausted. The equilibrium between supply and demand was false appearance whichmeans that the cell was not able to utilize oxygen. Using two factor variance analysistreating the mean value of PvO_2 and PvCO_2 of organs results were as follows: the PvO_2in liver was lowest and the PvCO_2 was highest, while in kidney it was on the contrary,which appeared to reflect its difference in anatomico-physiological characters. The renalPvCO_2 rose rapidly from the 3rd h which showed renal function insufficiency. The pH ofarterial blood was higher than that of venous, they decreased continuously alI throughthe course of shock.The blood pH parting with blood gases stabilizing showed that acid-osis was not induced by hypoxia.

关 键 词：休克 缺氧症 代谢 出血性 

分 类 号：R605.971[医药卫生—急诊医学]