低剂量电离辐射对小鼠免疫器官cAMP和儿茶酚胺含量的影响  

Effects of low dose ionizing radiation on cAMPand catecholamine contents in mice immune organs

作　　者：龚守良[1] 刘伟宏[1] 徐桂珍[1] 刘淑春[1] 刘树铮[1] 吴镇凤[1] 

机构地区：[1]长春白求恩医科大学放射生物教研室,白求恩医科大学放射治疗科

出　　处：《中国病理生理杂志》1994年第5期450-453,共4页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金

摘　　要：本文报道，７５ｍＧｙ（１２．５ｍＧｙ／ｍｉｎ）单次全身Ｘ射线照射后９小时用ＳＲＢＣ免疫Ｃ５７ＢＬ／６小鼠，在免疫后４天和７天脾脏、胸腺和下丘脑ｃＡＭＰ含量均降低，而在免疫后４天脾脏去甲肾上腺素、肾上腺素和酪氨酸含量均增高，免疫后７天肾上腺素含量仍持续增高，当连续γ射线６５ｍＧｙ（０．０１５ｍＧｙ／ｍｉｎ，６ｈ／ｄ）全身照射小鼠后即刻或２９小时后免疫，脾脏和下丘脑ｃＭＰ含量也均降低。提示，低剂量照射小鼠，使免疫器官儿茶酚胺释放增加，ｃＡＭＰ代谢降低，可能导致淋巴细胞增殖和免疫功能增强。C57BL/6 mice were immunized with SRBC 9 h after single 75 mGy( 1 2.5 mGy/min )whole-body X-irradiation. The cAMp contents of spleen,thymus and hypo-thalamus decreased 4 and 7 days after immunization,while spleen NE (norepinephrine),E(epinepherine)and Tyr( tyrosine)contents increased 4 days after immunization but Econtent kept increasing 7 days after immunization,C57BL/6 mice were immunized with SRBC after -irradiation with cumulative 65 mGy(0.015mGy/min, 6h/d).The spleen and hypothalamic cAMP contents were also Iowered in mice immunized immediately and 29 h after γ-irradiation.The results suggest hat the increasing release of catecholamineand the decrease of the cAMP metabolism in the immune organs may lead to the splenocyte proliferation and the enhancement of immune function.

关 键 词：辐射 电离 腺苷环 磷酸 去甲肾上腺素 肾上腺素 

分 类 号：R818.023[医药卫生—放射医学] R392[医药卫生—临床医学]