酸枣仁总生物碱镇静催眠作用的实验研究  

Study on sedative and hyponotic effect of total alkaloidfrom Semen Zizyphi Spinosae

作　　者：符敬伟[1] 乔卫[1] 陈朝晖[2] 

机构地区：[1]天津医科大学药学院,天津300070 [2]天津市儿童医院

出　　处：《天津医科大学学报》2005年第1期52-54,共3页Journal of Tianjin Medical University

摘　　要：目的:考察酸枣仁总生物碱对小鼠的镇静催眠作用。方法:采用镇静催眠观察对小鼠自主活动,协同戊巴比妥钠对小鼠睡眠作用的影响。结果:酸枣仁总生物碱(25～100mg/kg)灌胃可减少小鼠自发活动,显著延长阈上剂量戊巴比妥钠致小鼠睡眠时间,增加阈下剂量戊巴比妥钠睡眠动物数。结论:提示生物碱为酸枣仁中枢抑制作用的有效部位。Objective: In this paper the sedative and hyponotic effects of total alkaloids were studied. Methods: sedative and hyponotic as well as anticonvulsant experiments were made to observe the effect of total alkaloid from semen zizyphi spinosae on the spontaneous motion and hyponosis in mice. Results: The result showed that total alkaloid from Semen Zizyphi Spinosae could markedly inhibit spontaneous motion,enhance the sleeping number of pentobarbital sodium (subthreshold dosage; and prolong the sleeping time of pentobarbital sodium (superthreshold dosage;. Conclusion: The total alkaloid from Semen Zizyphi Spinosae possesses obvious sedative and hyponotic effects.

关 键 词：酸枣仁 总生物碱 镇静催眠 

分 类 号：R285.6[医药卫生—中药学]