卡维洛尔与美托洛尔降压疗效对比研究  

The comparative study on therapeutic efficacy of carvediloland metoprolol in patients with essential hypertension

作　　者：惠波[1] 王秉臣[2] 张峰[3] 蔡林[3] 金喆[3] 党群[3] 王佩显[1] 

机构地区：[1]天津医科大学总医院心内科,天津300052 [2]河北医科大学第二医院心内科 [3]天津市第一中心医院心内科

出　　处：《天津医科大学学报》2005年第1期66-67,70,共3页Journal of Tianjin Medical University

摘　　要：目的:对比研究卡维洛尔与美托洛尔对轻、中度原发性高血压的疗效及安全性。方法:83例轻、中度原发性高血压患者随机分为两组。A组29例(应用卡维洛尔),B组54例(应用美托洛尔)。先停用其他降压药后,A组和B组起始剂量均为12.5mgBid,渐增至最大显效量25mgBid或50mgBid。然后继续维持最大有效剂量至第8周末。结果:服药后第4、6、8周末血压与用药前比较有明显降低(P<0.05),A组与B组总有效率分别为79.31%和59.26%(P<0.05),治疗后心率均略有下降。卡维洛尔的不良反应较少。结论:与美托洛尔相比,卡维洛尔降压更加安全有效。Objective: To study the therapeutic efficacy and safety of carvedilol and metoprolol in patients with mild to moderate essential hypertention comparatively. Methods: 83 patients with mild to moderate essential hypertention were randomily divided into two groups:group A (29 patients;and B(54 patients;. The patients of group A received carvediol 12.5 mg Bid and those of group B received metoprolol 12.5 mg Bid; then increased to 25 mg or 50 mg Bid. The study continued for 8 weeks. Results: Blood pressure of group A decreased more significantly from the fourth week to the eighth week after carvedilol treatent than that of pretreatment (P<0.05;. The total effective rate of carvedilol and metoprolol were 79.31% and 59.26% respectively (P<0.05;. The heart rate was mild decreased and a lower incidence of adverse reactions occurred. Conclusion: Comparring with metoprolol,carvedilol is a safer and more effective antihypertension drug.

关 键 词：卡维洛尔 美托洛尔 高血压 

分 类 号：R972.4[医药卫生—药品]