红外光谱法测试高温融熔工艺对甲氨蝶呤植入剂结构的影响  

Determination of the structural change of methotrexate as an implant under the high-temperature fusion by infrared spectroscopy

作　　者：王世亮[1] 储成顶[1] 刘飞[1] 俞敏[1] 鲍玉婷[1] 马晓芹[1] 胡克良[2] 

机构地区：[1]合肥工业大学控释药物研究所,合肥230009 [2]中国科技大学理化中心,合肥230026

出　　处：《中国新药杂志》2005年第3期307-309,共3页Chinese Journal of New Drugs

基　　金：科技部基础研究快速反应支持项目(国科基字[2001]51号)

摘　　要：目的:观测甲氨蝶呤植入剂的高温融熔生产工艺对药物结构的影响。方法:测试该植入剂及各配方成分的红外光谱图,再以标准谱图比对,检查因结构变化而形成的吸收峰变化。结果:该植入剂图谱中,各配方成分的特征峰呈叠加状态,不多一峰,不少一峰。结论:该植入剂中药物结构未出现明显变化。Objective: To determine by IR whether the high-temperature fusion makes an impact on methotrexate structure. Methods: Comparison of the IR spectrum for the different formulae containing methotrexate to the standard IR spectrum was conducted. Results: All spectral characteristics between each formula showed no changes. Conclusion: The high-temperature fusion has few impacts on methotrexate structure.

关 键 词：甲氧蝶呤 植入剂 红外光谱 

分 类 号：R927.1[医药卫生—药学] R979.12