基于Excel软件的静脉滴注给药(一级并行)米氏消除药动学方程的数值解  

A Numerical method for plasma concentration of drugs obeying pa rallel first order and Michaelis-Menten clearance kinetics by intravenous infus ion administration based on Runge-Kutta algorithm and Microsoft Excel software

作　　者：苏银法[1] 

机构地区：[1]温州市第二人民医院药剂科,浙江温州325000

出　　处：《中国现代应用药学》2005年第2期145-148,共4页Chinese Journal of Modern Applied Pharmacy

基　　金：温州市科技局资助项目(Y2003A075)

摘　　要：目的　获得静脉滴注给药时(一级并行)米氏消除药物的血药浓度近似解。方法　根据四阶龙格库塔算法,采用Excel软件编写(一级并行)米氏消除药动学方程数值解的表格程序。结果　输入药动学参数(Vm,Km,Vd,ke)后,Excel表格输出任一次给药后某时刻的预期血药浓度。结论　这一表格程序是静脉滴注给药(一级并行)米氏消除药动学方程一种可靠的数值解法。OBJECTIVE To obtain a numerical method f or the plasma concentration of drugs obeying parallel first and Michaelis-Menten clearance kinetics by intravenous infusion administration.METHOD Microsoft Excel was used to write a Microsoft Excel spre adsheet based on four stage Runge-Kutta algorithm.RESULTS After inputting the pharmacokinetic parameters(Vm、Km 、Vd、ke),the Excel table displayed plasma concentration at mini-interval aft er the administration. CONCLUSION The four stage Runge-Kutta algorithm is a reliable numerical method of plasma concentration of drugs obeying parallel first order a nd Michaelis-Menten clearance kinetics by intravenous infusion administration.

关 键 词：药动学 EXCEL软件 米氏消除 龙格-库塔算法 静脉滴注 

分 类 号：R969.1[医药卫生—药理学] TP391.13[医药卫生—药学]