原发性肾小球疾病肾衰细胞免疫功能的临床研究  

Clinical study of cellar immunological function inprimary glomerular disease renal failure

作　　者：岳少姮[1] 徐岩[1] 孙建平[1] 曹彩霞[1] 张乐[1] 

机构地区：[1]青岛大学医学院附属医院,山东青岛266003

出　　处：《山东医药》2005年第10期12-13,共2页Shandong Medical Journal

摘　　要：目的研究原发性肾小球疾病肾衰(CRF)细胞免疫功能的临床变化情况,以寻找更好的控制CRF的措施。方法选择CRF患者59例为研究对象,观察CRF组与正常对照组的红细胞免疫功能、T淋巴细胞免疫功能、血清循环免疫复合物(CIC)的水平。结果与对照组比较,CRF的红细胞免疫功能及T淋巴细胞免疫功能均异常的显著降低(P<0.01),CIC显著升高(P<0.01)。结论CRF细胞免疫功能降低,红细胞免疫和T淋巴细胞免疫功能互相影响,在CRF的发病过程中起重要作用,促进患者细胞免疫功能的恢复对CRF治疗有重要意义。Objective To explore the clinical changes of cellar immunological function in renal failure caused by primary glomerular disease and to provide help for the treatment.Methods The immunological function of red cells and T lymphocytes the level of serum circular immune compounds (CIC) in control group and those of 59 patients suffered from primary glomerular disease renal failure (CRF) were measured.Results Compared with the controls,the immunological function of red cells and T lymphocytes in study group were significantly decreased (P<0.01),however,CIC increased (P<0.01).Conclusion The cells immunological function in CRF descend.The immunological function of red cells and T lymphocytes can affect each other.The role of the cells immunological function in CRF was obvious.The therapeutic strategies aiming at stimulation of the host cells immunological function should be designed.

关 键 词：原发性肾小球疾病 临床研究 淋巴细胞免疫功能 肾衰 红细胞免疫功能 血清循环免疫复合物 免疫功能降低 CRF 正常对照组 变化情况 研究对象 方法选择 发病过程 重要意义 RF治疗 CIC 患者 

分 类 号：R692.6[医药卫生—泌尿科学] R459.6[医药卫生—外科学]