曲安奈德有关物质检查方法的研究  

Study of Relative Substances in Triamcinolone Acetonide

作　　者：王昕[1] 左文坚[1] 

机构地区：[1]天津市药品检验所,天津300070

出　　处：《天津药学》2005年第2期27-29,共3页Tianjin Pharmacy

摘　　要：目的:建立高效液相色谱法测定曲安奈德有关物质的方法。方法:采用DiamonsilTMC18(150mm×4.6mm,5μm)色谱柱,甲醇-水(525∶475)为流动相,检测波长254nm。结果:曲安西龙与曲安奈德的线性范围分别为0.125～6.25μg/ml和0.25～12.5μg/ml,相关系数均为r=0.9999(n=7),最低检出量分别为0.5ng和1ng。结论:HPLC检查法简便、准确、灵敏,可准确测定杂质的含量。Object: To establish an HPLC method for detection of relative substances in Triamcinolone Acetonide.Methods:The chromatographic system consisted of C18 column and mobile phase of methanol-water (525∶475),The detection wavelength was set at 254 nm. Results:The linear of Triamlone and Triamcinolone Acetonide were the range of 0.125～6.25 μg/ml and 0.25～12.5 μg/ml,(r=0.999 9,n=7). The limits of detection for Triamlone and Triamcinolone Acetonide were 0.5ng and 1.0ng.Conclusion:The HPLC method was found to be practical with the advantages of simplicity, accuracy and sensitivity.

关 键 词：曲安奈德 有关物质 HPLC 

分 类 号：R972.2[医药卫生—药品]