胃食管反流病患儿食管压力监测及其临床意义  

Esophageal manometry and its clinical significance in children with gastroesophageal reflux diseases

作　　者：周雪莲[1] 欧弼悠[1] 章许平[1] 黄晓磊[1] 陈洁[1] 徐亚萍[1] 郑季彦[1] 

机构地区：[1]浙江大学医学院附属儿童医院,杭州310003

出　　处：《浙江医学》2005年第4期248-249,共2页Zhejiang Medical Journal

基　　金：浙江省教委资助项目(20010529)

摘　　要：目的探讨儿童胃食管反流病(GERD)的发病机理及食管压力监测在儿童GERD诊断中的应用价值。方法对30例经24h食管动态pH监测确诊有病理性胃食管反流的患儿进行食管压力监测,并设对照组进行对照。结果两组患儿下食管括约肌压力(LESP)、屏障压(BP)比较差别有显著性意义(均P<0.05)。短暂性下食管括约肌松驰(TLESR)现象发生例数差别也有显著性意义(P<0.05),下食管括约肌长度(LESL)差别无显著性意义(P>0.05)。结论TLESR在GERD发病中起重要的作用,但并不是唯一的原因;LESP和BP降低也起了主导作用,而LESL不起主要作用。Objective To explore the mechanism of gastroesophageal reflux diseases (GERD) and the application of esophageal manometry in the diagnoses of GERD in children. Methods Esophageal manometry was applied in 30 children with pathological gastric acid reflux confirmed by 24 hr esophageal pH monitoring. Results Lower esophageal sphincter pressure (LESP) and barrier pressure (BP) between gaster and esophagus in patients were significantly lower than those in controls, whereas the difference of lower esophageal sphincter length (LESL) between the two groups was not significant. The frequency of transitory lower esophageal sphincter relaxation (TLESR) was significantly higher in patients compared to controls. Conclusion It suggests that LESP, BP and TLESR may be the major pathogenetic factors of GERD in children, while LESL may not be an important factor.

关 键 词：胃食管反流病 压力监测 临床意义 患儿 病理性胃食管反流 食管动态pH监测 下食管括约肌压力 括约肌长度 TLESR 显著性 应用价值 发病机理 主导作用 LESP 24h 对照组 差别 肌松驰 儿童 

分 类 号：R725.7[医药卫生—儿科]