C-反应蛋白对胸腔积液诊断的临床意义  

Value of pleural fluid C-reactive protein in diagnosis of pleural effusions

作　　者：万锦平[1] 张素娟[1] 刘皓[1] 

机构地区：[1]苏州大学附属三院江苏常州第一人民医院呼吸科,213003

出　　处：《临床肺科杂志》2005年第2期172-173,共2页Journal of Clinical Pulmonary Medicine

摘　　要：目的探索C-反应蛋白(CRP)对胸腔积液诊断的临床意义。方法采用透射比浊度法测定68例不同性质胸腔积液患者的胸水CRP和血清CRP水平,以及其比值。结果漏出液中CRP水平(6.1±3.1)mg/L明显低于渗出液中CRP水平(24.7±4.5)mg/L,(P<0.001)。同时,胸水CRP水平与血清CRP水平的比值,漏出液(0.7±0.5)明显低于渗出液(2.1±0.6)(P<0.001)。另外,化脓性胸膜炎胸水CRP水平(38.2±7.7)mg/L显著升高,其胸水CRP水平与血清CRP水平之比值(4.8±2.5)也明显升高。胸水CRP水平高于35.0mg/L对于化脓性胸腔积液的诊断灵敏度81.25%,特异性61.9%。结论　胸水CRP水平测定有助于鉴别胸腔积液之渗出液和漏出液,而且,高水平的胸水CRP被证明是诊断化脓性胸腔积液较为迅速且准确的方法。Objective To explore the value of C-reactive protein (CRP) in the diagnosis of pleural effusions. Methods CRP levels of pleural fluids and serums in 68 patients with different types of pleural effusions were detected by nephelometer and the ratios of pleural fluids to serums were also obtained. Results Pleural fluid CRP levels were significantly lower in the transudate group than in exudate group(6. 1±3. 1mg/L and 24. 7±4. 5mg/L respectively, P<0. 001). Also, the ratio of pleural fluid to serum (4. 8±2. 5) in purulent pleurisy were significantly higher than those in the other subgroups. Conclusion The pleural CRP level may be helpful in discriminating exudative from transudative pleural effusions. Furthermore, higher CRP levels may prove to be a rapid, practical and accurate method of differentiating purulent pleurisy from other exudates types.

关 键 词：C-反应蛋白 胸腔积液 诊断 

分 类 号：R561[医药卫生—呼吸系统]