克山病病区粮喂养大鼠心肌内心钠素含量变化及硒和维生素对其影响  

EFFECTS OF VE AND SE ON MYOCARDIAL ANP IN RATS

作　　者：刘晓亮[1] 许丽艳[1] 张秀云[1] 刘松岩[1] 王凡[1] 朱德志[2] 马丽[2] 肖淑芬[2] 

机构地区：[1]白求恩医科大学地方病研究所 [2]白求恩医科大学第一临床学院核医学科

出　　处：《中国地方病防治》1994年第4期203-204,共2页Chinese Journal of Control of Endemic Diseases

基　　金：国家自然科学基金资助项目;霍英东教育基金资助项目

摘　　要：本文用低硒的克山病病区粮喂养大鼠,证明其心肌中心钠素(ANP)含量明显增高,而在补充硒、维生素E(VE)后均可使其含量下降,并且具有一定的量效关系,尤其是硒和VE的联合补充使心肌中ANP含量明显降低,接近饲非病区粮和常规食水平。表明二者对心脏内产生和释放ANP具有明显的影响,据此推论硒和VE的联合缺乏可能就是造成病区粮饲养动物心肌内ANP含量增加的主要原因。In this paper,authors investigated the effects of selenium (Se) and vitamin E (VE) on myocar-dial Atrial Natriuretic Polypeptide (ANP) contents in rats fed grains from a Keshan Disease (KD) endemic area. The results showed that myocardial ANP contents was significantly increased in rats and the change could be effectively reduced through Se or/and VE supplementation to the diet. A u-nited effort of Se and VE was better. There were a good quantity-activity correlation between change in myocardial ANP contents and amounts of Se or/and VE supplementation. The present study suggests that myocardium of KD is a hypothyroid state. Se or/and VE supplementation protected the thyroxine 5'- monodeiase, enhanced T3 contents of tissues and improved thyroid hormone deficiency state, besides improved myocardial free radical metabolism uncontrolled state.

关 键 词：克山病 硒 维生素E 心钠素 心肌 

分 类 号：R542.3[医药卫生—心血管疾病]