膳食低钙在克山病心肌坏死发生中的作用——补蛋白和钾或镁的对比实验研究  

EFFECTS OF LOW CALCIUM IN DIET ON PATHOGENESIS OF MYOCARDIAL NECROSIS OF KESHAN DISEASE, CONTRASTIVE EXPERIMENT OF SUPPLEMENT WITH PROTEIN AND POTASSIUM OR MAGNESIUM

作　　者：康德仁[1] 盖丽云[1] 郭城浩 孙波[1] 李成库[1] 卜凤泉[1] 王凡[1] 李广生[1] 

机构地区：[1]白求恩医科大学地方病研究所

出　　处：《中国地方病防治》1994年第6期328-331,共4页Chinese Journal of Control of Endemic Diseases

基　　金：国家自然科学基金资助项目

摘　　要：模仿克山病病区易感人群膳食组成的病区粮偏食,虽然多种成分均偏低,但除了低硒外低钙最突出,已经证明单纯补钙就可以明显减轻缺氧性心肌坏死,同时补钙和硒及VE效果更好。本实验用病区粮偏食补蛋白+KCl和补蛋白+MgCl_2食,也不能则显减轻心肌坏死程度,而单纯补钙就可以明显减轻心肌坏死程度和心重/体重比,进一步证实偏食中除低硒外,低钙和缺氧性心肌坏死关系最密切,膳食低钙在克山病心肌坏死发生中有重要作用。It had been convinced that monotonous diet which imitated the composition of diet for the susceptible population of Keshan disease was prominently low in calcium and selenium, although many components of the diet were on the low side. The anoxic myocardial necrosis was significantly decreased when the monotonous diet was supplemented with only calcium. In this experiment the monotonous diet was supplemented with casein and KC1 or casein and MgCl2, the anoxic myocardial necrosis was not significantly decreased, but supplement with only calcium still significantly decreased the,degree of anoxic myocardial necrosis and the ratio between heart weight and body weight. It Was further confirmed that besides low in selenium, low in calcium in the monotonous diet was closely related to the anoxic myocardial necrosis. Thus, low in calcium of monotonous diet among the susceptible population of Keshan disease plays an important role in the pathogenesis of myocardial necrosis in Keshan disease.

关 键 词：钙 饮食 心肌坏死 克山病 动物实验 

分 类 号：R542.301[医药卫生—心血管疾病] R591.101[医药卫生—内科学]