克山病病区粮饲养大鼠血栓素前列环素水平及其与硒维生素E的关系  

Relationship among prostacyclin,thromboxane or Wistar rats fed with grain from Keshan disease area and Selenium,Vitamin E

作　　者：刘为民[1] 李广生[1] 张秀云[1] 王凡[1] 朱德志[1] 马力[1] 肖淑芬[1] 刘雅言[1] 

机构地区：[1]白求恩医科大学应用基础医学研究所,白求恩医科大学一院核医学科,中国科学院长春应用化学研究所

出　　处：《中国地方病学杂志》1994年第2期70-73,共4页Chinese Jouranl of Endemiology

基　　金：国家"八五"攻关项目

摘　　要：研究了硒和维生素Ｅ（ＶＥ）对大鼠血浆和心肌血栓素（ＴＸＡ２）、前列环素（ＰＧＩ２）水平及ＴＸＡ２／ＰＧＩ２比值的影响。发现饲低硒、ＶＥ的克山病病区粮组动物在谷胱甘肽过氧化物酶降低和自由基净含量、脂质过氧化物（ＬＰＯ）浓度增高的同时，ＴＸＡ２水平增高、ＰＧＩ２水平降低、ＴＸＡ２／ＰＧＩ２比值增高；加硒或／和ＶＥ对纠正上述变化有相似而又不尽相用的效果，而以联合补充效果量佳。本研究结果提示硒和ＶＥ缺乏通过影响花生四烯酸代谢参与克山病缺血缺氧性心肌坏死的发生发展，其机制可能与二者缺乏，抗氧化能力降低，生成过量自由基和ＬＰＯ，抑制了ＰＧＩ２合成酶的作用并促进ＴＸＡ２形成有关。In this paper, we studied the effects of Selenium or/and vitamin E on the production of prostacylin (PGI2), thromboxane A (TXA2), TXA2/PGI2 in the plasma and myocardium of Wistar rats. We discovered that glutathione peroxidase activity and PGI2 level of Wistar rats fed with grain from Keshan Disease (KD)area were significantly higher than those of the control,but free radical, lipid peroxides concentration, TXA2 and TXA2/PGI2 were increased. There were resemblances in the effects of adding Selenium or/and Vitamin E,but also showing some differences. If, selenium and Vitamin E were supplemented together,so much the better. The results showed that selenium and Vitamin E deficency may have modulated arachidonic acid vitamin E metabolism and played a part in developing of KD myocardial necrosis. It was likely that the excessive lipid peroxides which were formed as a result of free radical formation inhibited PGI2 synthesis.

关 键 词：克山病 硒 维生素E 血栓素 

分 类 号：R542.302[医药卫生—心血管疾病]