我国鼠疫菌大质粒的特性及其流行病学意义  

Study on the features and epidemiological signifficances of large plasmids from Yersinia pestis in China

作　　者：李敏[1] 于晓涛[1] 金丽霞[1] 黎莉[1] 祁芝珍[1] 姚桂珠[1] 

机构地区：[1]青海省地方病防治研究所

出　　处：《中国地方病学杂志》1994年第4期223-225,共3页Chinese Jouranl of Endemiology

基　　金：青海省卫生厅资助

摘　　要：用琼脂糖凝胶电泳的方法检测分离自我国各疫源地，１７个生态型的２００６株鼠疫菌的大质粒。结果表明，我国鼠疫菌含具有分类属性的大质粒共三类（５２，６５，９２Ｍｄ）。６５Ｍｄ质粒在各疫源地均有分布，５２、９２Ｍｄ质粒仅存在于青藏高原喜马拉雅旱獭疫源地。含５２Ｍｄ质粒的菌株分布在祁连山南、北麓及青海湖的环湖地区，带９２Ｍｄ质粒的菌株则分布在西藏那曲周围的唐古拉地区及青海的玉树、曲麻莱等地。鉴于这两类质粒有其独特的分布区，可将大质粒分子量的差异作为青藏高原喜马拉雅旱獭疫源地内区分鼠疫菌生物亚型的指标之一。The features of large plasmids from 2006 strains of Yersinia pestis collected from every plague natural fool in China were studied using the method of Agrose electricphocise. The results showed that there were three kinds of large plasmid with the specificity of clssification existed among 17 ecotypes of Yersinia pestis,i.e 52,65 and 92 MD plasmids. It was proposed that diversities of Molecular weights in the plasmid he used as one of the indices to classify biological subtype of Yersinia pestis in the Marmota Himalayana plague natural fici in Qinghai-Tibetan plateau

关 键 词：质粒 分布 鼠疫杆菌 流行病学 

分 类 号：R516.801[医药卫生—内科学]