克山病致病因素对大鼠心肌线粒体α－磷酸甘油脱氢酶的影响  

Effect of the pathogenic factors of Keshan Disease on activity of myocardial mitochondria α-Glycerophosphate Dehydrogenase in rats

作　　者：刘晓亮[1] 许丽艳[1] 周余来[1] 刘松岩[1] 王凡[1] 

机构地区：[1]长春白求恩医科大学地方病研究所

出　　处：《中国地方病学杂志》1994年第5期261-263,共3页Chinese Jouranl of Endemiology

基　　金：国家自然科学基金

摘　　要：测定了克山病病区粮喂养大鼠心肌线粒体α－磷酸甘油脱氢酶（ａ－ＧＰＤ）活性，并观察了硒和维生素Ｅ对该酶的影响。结果表明，病区粮组大鼠心肌线粒体α－ＧＰＤ活力明显低于非病区粮组和常规．食组，并在补０．１μｇ／ｇ＋８００μｇ／ｇＶＥ后，α－ＧＰＤ活性升高与病区粮组比较有显著差异、本实验结果提示：１、饲克山病病区粮大鼠心肌线粒体α－ＧＰＤ活力的降低，此时的心肌可能处于甲状腺激素功能低下状态．２、硒（０．１μｇ／ｇ）＋维生素Ｅ（８００μｇ／ｇ）的补充可以升高该酶活性，改善甲状腺激素功能不足状态。In this paper, writters investigated the myocardial mitochondria α-glycerophosphate dehydrogenase(α-GPD)activity of rats fed grains from a Keshan disease (KD) endemic areas and effects of Se and VE on α-GPD. The results showed that myocardia mitochondria α-GPD activity was significantly reduced in endemic group than that in non-endemic group and stock group. The activity of α-GPD was significantly increased through Se (0.1μg/g) +VE(800μg/g) supplementation to the diet. The results suggested that:1 myocardial mitochondria α-GPD activity of rats red grains from a KD areas was decreased, indicating that myocardium of endemic group was in a thyroidhormone-deficient status. 2 Se and VE can improve thyroid hormone deficient status.

关 键 词：克山病 硒 维生素E α-GPD 

分 类 号：R542.302[医药卫生—心血管疾病]