单核细胞趋化蛋白-1在口腔鳞癌中的表达及意义  

The Expression of Monocyte Chemoattractant Protein-1 and Its Clinical Significance In Human Oral Squamous Cell Cancer

作　　者：杨建斌[1] 冯红超[1] 宋宇峰[1] 

机构地区：[1]贵阳医学院附院口腔科,贵州贵阳550004

出　　处：《贵阳医学院学报》2005年第2期111-113,共3页Journal of Guiyang Medical College

基　　金：贵州省第二批跨世纪人才省政府专项基金--黔科合人专字(2000)9813号

摘　　要：目的: 探讨单核细胞趋化蛋白-1(monocytechemoattractantprotein-1,MCP-1)在口腔鳞癌组织中的表达及其临床意义。方法:应用免疫组织化学SABC法检测41例口腔鳞癌组织中MCP-1的表达,并以10例正常口腔黏膜组织作为对照。结果:口腔鳞癌组织中MCP-1的表达较正常组织增加,差异有统计学意义;口腔鳞癌中MCP-1阳性表达主要分布在癌细胞和巨噬细胞的胞浆中,MCP-1的表达与肿瘤细胞的分化和转移有关。结论:MCP-1可能参与了口腔鳞癌的发展和转移。Objective: To study the expression of monocyte chemoattractant protein-1 (MCP-1)in the tissue of oral squamous cell cancer (OSCC) and its clinical significance. Methods: The expression of MCP-1 in 41 cases of OSCC and 10 specimens of normal oral epithelial tissue was assessed with SABC immunohistochemical method. Results: The expression of MCP-1 was higher in OSCC than in normal oral mucous tissue. There was a relation between the expression of MCP-1 and tumor differentiation and lymphatic metastasis. Conclusion: MCP-1 might participate the progress and lymphatic metastasis of human OSCC.

关 键 词：单核细胞趋化蛋白-1 表达及 免疫组织化学SABC法 口腔鳞癌组织 MCP-1 口腔黏膜组织 临床意义 正常组织 巨噬细胞 阳性表达 肿瘤细胞 统计学 癌细胞 转移 

分 类 号：R587.2[医药卫生—内分泌] R737.25[医药卫生—内科学]