乙酸乙酯键联卟啉的合成与表征  

Synthesis and Characteristics of Ethyl Chloroacetate Bonded Porphyrin

作　　者：范少华[1] 崔玉民[1] 

机构地区：[1]阜阳师范学院化学系,安徽阜阳236032

出　　处：《河南科技大学学报（自然科学版）》2005年第2期98-101,i007,共5页Journal of Henan University of Science And Technology:Natural Science

基　　金：安徽省教育厅自然科学基金资助项目(2004kj303);安徽省"十五"优秀人才培养计划资助项目

摘　　要：从5,10,15,20-四苯基卟啉合成5-(p-β-乙酸乙酯基氨基苯基)-10,15,20-三苯基卟啉5,10,15,20-四苯基卟啉(A)与发烟硝酸反应得到5-(对-硝基苯基)-10,15,20-三苯基卟啉(B),产率48.7%;B与二氯化锡进行还原反应得到5-(对-氨基苯基)-10,15,20-三苯基卟啉(C),产率72.0%;C在无水碳酸钾和无水碘化钾催化下与氯乙酸乙酯进行亲核取代反应得到5-(p-β-乙酸乙酯基氨基苯基)-10,15,20-三苯基卟啉(D),产率8.5%。该方法的反应条件温和,合成路线短,纯化方法简单。5-(p-β-ethyl acetate aminophenyl)-10,15,20-triphenyl porphyrin (D) was synthesized from 5,10,15,20-tetraphenyl porphyrin (A):5-(p-nitrobenyl)-10,15,20-triphenyl porphyrin (B) was obtained in 48.7% yield through (A) reaction with HNO_3,5-(p-amino phenyl)-10,15,20-triphenyl porphyrin (C) was obtained in 72.0% yield through (B) reaction with SnCl_2·2H_2O,and (D) was obtained in 8.5% yield through (C) reaction with ethyl chloroacetate in the presence of anbydrous K_2CO_3 and KI.This process has the advantages of convenient manipulation,mild reaction conditions and simple purifying method.

关 键 词：合成与表征 三苯基卟啉 四苯基卟啉 键联 氨基苯基 亲核取代反应 氯乙酸乙酯 无水碳酸钾 硝基苯基 发烟硝酸 还原反应 二氯化锡 反应条件 合成路线 纯化方法 产率 碘化钾 酯基 

分 类 号：O614.33[理学—无机化学] O626.32[理学—化学]