小剂量倍他乐克治疗充血性心力衰竭对血浆脑钠尿肽水平的影响  

Effect of low dose Betaloc on plasma brain natriuretic peptide level in patients with congestive heart failure

作　　者：孙静[1] 钱安斌[1] 

机构地区：[1]宁波市第一医院内科,浙江宁波315010

出　　处：《心脏杂志》2005年第2期140-141,144,共3页Chinese Heart Journal

摘　　要：目的观察小剂量倍他乐克治疗充血性心力衰竭(CHF)后,患者血浆脑钠尿肽(BNP)水平的改变。方法选择心功能Ⅲ～Ⅳ级心衰患者31例,在常规抗心衰基础上加用小剂量倍他乐克,观察治疗前后血浆BNP水平的变化。结果心率明显减慢,心胸比和血压均较治疗前降低,左室舒张末期内径(LVDd)缩短,左室射血分数(LVEF)则较治疗前提高,BNP值显著降低,总有效率达81%。结论小剂量倍他乐克治疗CHF可使BNP值显著下降,动态监测患者血浆BNP水平有助于了解CHF治疗效果及预后。AIM:To observe plasma brain natriuretic peptide level of patients with congestive heart failure (CHF) treated with low dose Betaloc. METHODS: We chose 31 heart failure patients with Ⅲ～Ⅳ New York Heart Association (NYHA)functional classification,and used low dose Betaloc on the basis of traditional treatment,then observed the change in plasma brain natriuretic peptide level during the treatment. RESULTS:After the treatment,patients' heart rate, blood pressure, cardio-thoracic ratio and LVDd all declined,but LVEF increased. The value of BNP declined obviously, and the total effective rate was 81%.CONCLUSION: The value of BNP declined obviously after the use of the Betaloc, which may help to detrmine the therapeutic effect and prognosis for CHF.

关 键 词：脑钠尿肽 倍他乐克 心力衰竭 充血性 

分 类 号：R541.61[医药卫生—心血管疾病]