自拟乙肝解毒方联合拉米夫定治疗慢性乙型肝炎27例临床研究  

A comparison study of self-made Yi-Gan-Pai-Du-Tang with lamivudine in treatmenting patients with chronic hepatitis B

作　　者：林屹[1] 黄贤樟[2] 佘世锋[1] 夏洪涛[1] 

机构地区：[1]广州中医药大学中山附属医院,1528400 [2]香港浸会大学中医药学院

出　　处：《现代消化及介入诊疗》2005年第1期17-19,共3页Modern Interventional Diagnosis and Treatment in Gastroenterology

摘　　要：目的观察自拟乙肝解毒方(乙肝解毒方)联合拉米夫定治疗慢性乙型肝炎的效果。方法79例慢性乙型肝炎患者随机分成三组,分别给予乙肝解毒方(中药组)、乙肝解毒方联用拉米夫定(联合用药组)、拉米夫定(西药组)治疗,3个月为一疗程,观察治疗过程中患者ALT、HBV-DNA定量及HBeAg的变化。结果在改善肝功能方面,中药组及联合用药组明显优于拉米夫定组(P<0.05),中药组与联合用药组疗效相当(P>0.05);在降低HBV-DNA定量及HBeAg阴转方面,联合用药组作用最强,明显优于其它两组(P<0.05)。结论乙肝解毒方联用拉米夫定可提高抑制乙肝病毒复制及改善肝功能的疗效。Objective To observe the clinical efficacy of Self-made Yi-Gan-Pai-Du-Tang with Lamivudine on Chronic hepatitis B. Methods Seventy-nine patients with chronic hepatitis B were randomly divided into three groups. One group was treated with Toxin-Expelling Formula to Hepatitis B only, one was treated with Self-made Yi-Gan-Pai-Du-Tang combined with Lamivudine, the other was treated with Lamivudine only. During the period of treatment (3 months), ALT、the titer of HBV-DNA and the change of HBeAg were observed. Results Chinese traditional medicine and combined treatment preceded Lamivudine in improving liver function (P < 0.05). Chinese traditional medicine corresponded with combined treatment in improving liver function (P > 0.05). In reducing the titer of HBV-DNA and positive rate of HBeAg, the combined treatment preceded other two groups (P < 0.05). Conclusion The Toxin-Expelling Formula to Hepatitis B combined with Lamivudine has an affirmative effects in inhibiting the reproduction of hepatitis B virus and improving the liver function.

关 键 词：拉米夫定治疗 解毒方 临床研究 自拟 慢性乙型肝炎患者 HBEAG阴转 DNA定量 乙肝病毒复制 联合用 中药组 治疗过程 HBV 肝功能 西药组 ALT 联用 疗效 

分 类 号：R512.62[医药卫生—内科学] R289.5[医药卫生—临床医学]