机械通气致下呼吸道黄杆菌感染的临床分析  

Lower respiratory tract infection caused by flavobacterium after machinery ventilation and clinical characteristics analysis

作　　者：张黎川[1] 

机构地区：[1]大连大学附属中山医院,辽宁大连116001

出　　处：《现代医药卫生》2005年第10期1191-1192,共2页Journal of Modern Medicine & Health

摘　　要：目的:探讨黄杆菌属致下呼吸道感染的临床特点及对常用抗生素的耐药情况。方法:分析我院六年来机械通气致下呼吸道黄杆菌感染的11例临床资料,平板稀释法测定常用抗菌药物对该菌株的最低抑菌浓度,采用法国生物梅里埃公司API系统进行细菌学鉴定,以美国国家实验室标准化委员会NCCLS的标准判定结果。结果:全部应用广谱抗生素,年龄>60岁者8例,机械通气到发生黄杆菌感染的平均时间为18天,死亡4例;耐药率高,仅对头孢哌酮/舒巴坦、复方磺胺甲恶唑、哌拉西林、左氧氟沙星等较敏感。结论:机械通气致下呼吸道黄杆菌感染常发生在基础状态较差,机械通气时间较长,且长期应用广谱抗生素的老年患者,临床表现常无特征性,细菌耐药严重。Objective:To observe clinical characteristics of lower respiratory infection caused by Flavobacterium and its drug Susceptibility to commom antibotics after machinery ventilation.Methods:Over the past6years,11clinical cases of Flavobacteriuminfection with lower respiratory under machinery ventilation had been studied,during the study process,the method of agar allution,API system by Bio-Mercux.and NCCLS standard were used to determine the minimumbacteriostatic concentration of common antibacterial drugs,identify bacteria,and evaluate the results respectively.Results:While broad spectrumantibiotics was used for all cases,among which8over60years old and6were COPD,the average time from using respirator to Flavobacterium infection was18days and4cases had died.It was only sensitive to cefoperazone/sulbactam,trimethoprim/sulfamethoxazole、piperacillin、Levofloxacinand etc.Conclusion:Hospital acquired lowrespiratory tract infection caused by Flavobacterium under machinery ventilation developed most commonly in old patients with poor base situation who suffered fromlongtime antibiotic overuse and longtime usage of respirator.No unique clinical features revealed.The clinical isolates are highly resistant.The death rates was high.

关 键 词：黄杆菌感染 临床分析 头孢哌酮/舒巴坦 复方磺胺甲恶唑 广谱抗生素 下呼吸道感染 最低抑菌浓度 机械通气时间 常用抗生素 平板稀释法 细菌学鉴定 API系统 NCCLS 左氧氟沙星 耐药情况 临床特点 黄杆菌属 临床资料 抗菌药物 

分 类 号：R654.2[医药卫生—外科学] R978.11[医药卫生—临床医学]