精喹禾灵的亚慢性毒性研究  

Study on Subchronic Toxicity of Quizalofop-p-ethyl to Rats

作　　者：孙建析[1] 顾刘金[1] 杨校华[1] 陈琼姜[1] 俞少勇[1] 吴立仁[1] 乐俊仪[1] 

机构地区：[1]浙江省医学科学院卫研所,杭州310013

出　　处：《环境与职业医学》2005年第2期149-150,共2页Journal of Environmental and Occupational Medicine

摘　　要：[目的]探讨精喹禾灵对大鼠的亚慢性毒性,求出最大无作用剂量。[方法]按照GB15 670 1995《农药登记毒理学试验方法》。[结果]精喹禾灵13 0 0mg/kg饲料总摄食量、增重及食物利用率低于对照组,脑/体比、心/体比、肺/体比、肝/体比、肾/体比均高于对照组,睾丸重量及睾丸/体比低于对照组。43 3mg/kg饲料组及13 0 0mg/kg饲料组睾丸组织病理学检查可见组织形态学改变。[结论]精喹禾灵可引起SD大鼠睾丸生殖细胞病变,最大无作用剂量为(10 .42±0 65 )mg/(kg·d)。Objective] To study the subchronic toxicity of quizalofop-p-ethyl to rats and obtain NEL.[Methods] According to GB 15670-1995“Toxicological test methods of pesticides for registration”. [Results] The decrease in food consumption,body weight,food efficiency,testes weight and the organ coefficient of testes,the increase in the organ coefficients of brain,heart,lung,liver,kidney,were observed at the dose of 1,300 mg/kg food.The morphological changes of testes were found at the doses of 433 mg/kg food and 1,300 mg/kg food.[Conclusion] The reproductive effects of quizalofop-p-ethyl in rats was shown and its NEL is (10.42±0.65) mg/(kg·d).

关 键 词：喹禾灵 毒性研究 最大无作用剂量 组织病理学检查 亚慢性毒性 食物利用率 形态学改变 对照组 试验方法 睾丸重量 细胞病变 大鼠睾丸 毒理学 摄食量 饲料 

分 类 号：R996[医药卫生—毒理学] R995[医药卫生—药学]