新生儿黄疸脑血流灌注显像和预后评估的关系  

A study on relations between the SPECT cerebral blood flow imaging in neonatal jaundice and the prognostic evaluation

作　　者：严越秀[1] 彭祖光[1] 周路[1] 莫伟雄[1] 张小玲[1] 乔萍[1] 肖力[1] 

机构地区：[1]肇庆市第一人民医院儿科,广东肇庆526021

出　　处：《中国基层医药》2005年第4期442-443,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的　探讨新生儿不同水平血清总胆红素(TSB)的单光子发射计算机断层(SPECT)脑血流灌注显像特点和预后评估的关系。方法　对2 8例不同水平TSB新生儿进行脑血流灌注显像,并进行新生儿2 0项行为神经测定、脑干听觉诱发电位检查;对2 5例患儿的智力、听力及神经系统检查进行1～3年随访。结果　显像异常率为:≥2 2 0 . 5 μmol/L组,11% ;≥342 . 0 μmol/L组,4 3% ;≥4 2 .7 5 μmol/L组,83%。显像异常9例中,无后遗症者2例,有轻度后遗症者2例,有严重后遗症者2例,死亡3例。结论　脑血流SPECT断层显像能对胆红素脑病做出早期诊断,并对病灶定位及预后判断有较大帮助。Objective To study the relations between the distributive characteristics of SPECT regional cerebral blood flow(rCBF) imaging in neonatal hyperbilirubinemia and the prognostic evaluation.Methods The twenty-eight neonates with various total serum bilirubin(TSB) were examined by 99Tcm-ethylcysteinate dimmer(ECD) SPECT cerebral blood flow imaging,at the same time neonatal behavioral neurological assessment(NBNA) and brainstem auditory electrograph responses(BAER) were performed and followed up for 1 to 3 years the intelligence,hearing ability and nervous system of infant patients.Results The abnormal ratio were ≥220.5μmol/L,11%(1/9);≥342.0μmol/L,43%(3/7);≥427.5μmol/L,83%(5/6) respectively.Within the 9 cases with the abnormal rCBF imaging,there were not sequelae 2 cases,there were light sequelae 2 cases,there were serious sequelae 2 cases,died moreover 3 cases.Conclusion The SPECT rCBF imaging can make a earlier diagnosis to bilirubin-encephalopathy and can help locate focus of the disease and prognostic evaluation.

关 键 词：新生儿黄疸 脑血流灌注显像 预后 评估 

分 类 号：R722.17[医药卫生—儿科]