氨氯地平与尼群地平治疗高血压的多中心平行对照研究  

Multicenter Parallel Study of Amlodipine Versus Nitrendipine in Treatment Essential Hypertension

作　　者：王宪衍[1] 龚兰生[1] 郭冀珍[1] 王孝铭[1] 刘玉慧[2] 叶绪英[2] 张国元[3] 杨培林[4] 

机构地区：[1]上海第二医科大学附属瑞金医院,上海市高血压研究所,200025 [2]大连医学院附属第二医院 [3]第二军医大学附属长征医院 [4]上海第二医科大学附属第九人民医院

出　　处：《中国高血压杂志》1994年第2期104-107,共4页

摘　　要：采用多中心、随机、单盲、组间、平行对照的方法对488例原发性高血压患者进行氨氯地平或尼群地平4周治疗观察，显示氨氯地平的降压有效率为90．4％，较尼群地平显著为高。不良反应较少，安全性好。每日只需服药1次，剂量5～10mg，方便病人。In a multicenter, randomized l sing1e blind and para11e1 study, 488 patients with essential hypertension were completed 4 week t1'eatment with amlodipine 0r nitrendipine. It showed that the response rates of amlodipine were 90. 4% and it was higher than that of nitrendipine. Its adverse effets were fewer than those of nitrendipine. In conclusi0n,amlodipine is a safe and effective antihypertensive agent. Its once daily (5~ 1Omg) dosage makes it very c0nvenient for patients.

关 键 词：氨氯地平 尼群地平 高血压 降压药 

分 类 号：R972.4[医药卫生—药品]