^(99)Tc-MDP对绝经后骨质疏松骨吸收、骨生成的影响  

The effect of the bone resorption and osteogenesis in postmenopausal osteoporosis's patients with ^(99) Tc-MDP

作　　者：张萌萌[1] 窦宇[1] 郭忠[1] 吴乃宝[1] 张彩杰[1] 唐萍[1] 张宗英[1] 

机构地区：[1]吉林大学第四医院核医学科,吉林长春130011

出　　处：《中国实验诊断学》2005年第2期255-256,共2页Chinese Journal of Laboratory Diagnosis

摘　　要：目的　观察99Tc- MDP[99锝 亚甲基二膦酸盐]治疗10 2例绝经后骨质疏松患者骨代谢指标变化。方法　监测绝经后骨质疏松患者治疗前后BGP(骨钙素)、IL -1(白细胞介素- 1)、IL 6 (白细胞介素- 6 )、IGF -I(类胰岛素样生长因子I)、IGF -II(类胰岛素样生长因子II)、E2 (雌二醇)及骨密度测定。结果　治疗后6个月患者骨密度增加,BGP水平升高,IL -1、IL- 6水平降低,IGF I、IGF II水平升高。结论　99Tc -MDP抑制骨丢失,提高成骨细胞活性,增加骨密度作用确切。Objective We observed the change of the bone's metabolizable with the 102 Osteoporosis's Patients in postmenopausal women treated by 99 Tc-MDP. Methods Following indicators have been observed dymainically, including BGP, IL-I, IL-6, IGF-I, IGF-II, E_2, bone desity and so on. Results It Was showed that the treatment of 99 Tc-MDP could lower the level of interleukins, raise the level of IGF-I, IGF-II, increase bone mineral content and Ostocalcin. Conclusion It is aure that the treatment of 99 Tc-MDP could inhibite the lose of bone matrix, increase the activity of Ostoblasts and bone mineral content.

关 键 词：99锝(^9Tc) 亚甲基二膦酸盐(MDP) 骨质疏松 骨吸收 骨形成 骨密度 

分 类 号：R817[医药卫生—影像医学与核医学]