B型利钠肽在急性呼吸困难鉴别诊断中的应用研究  

Applied Research of bed-side B type natriuretic peptide assays in differentiating acute dyspnea

作　　者：孙晓鸥[1] 姜朝晖[1] 赵荣[2] 

机构地区：[1]辽宁省鞍山市中心医院,辽宁鞍山114001 [2]辽宁省鞍山市鞍钢铁东医院

出　　处：《中国实验诊断学》2005年第2期263-265,共3页Chinese Journal of Laboratory Diagnosis

摘　　要：目的　探讨床旁B型利钠肽(BNP)测定对急性呼吸困难鉴别诊断的敏感性、特异性和准确性。方法　采用美国博适 Triage干式快速定量心力衰竭/心肌梗死诊断仪对36 7例心源性和非心源性呼吸困难患者床旁BNP测定。结果　不同心功能分级患者BNP水平不同;BNP水平小于6 0pg/ml患者基本可诊断为非心源性呼吸困难;BNP水平大于1 0 0pg/ml但小于50 0pg/ml患者需考虑心源性呼吸困难可能;大于50 0pg/ml患者基本可诊断为心源性呼吸困难。结论　BNP水平高低是鉴别心源性和非心源性呼吸困难可靠的指标。Objective To investigate sensitivity, specialty and accuracy of B type natriuretic peptide(BNP) assays in differentiating cardiac and non-cardiac dyspnea. Methods BNP levels of 351 patients with cardiac or non-cardiac dyspnea were measured by Triage CHF/AMI analyzer made by American Biosite company. Results BNP levels were different in different cardiac function patients according to NYHA; When BNP level is less than 60 pg/ml, non-cardiac dyspnea can be diagnosed; when BNP level is between 100 pg/ml and 500 pg/ml, cardiac dyspnea should be considered; when BNP level is more than 500 pg/ml, cardiac dyspnea can be diagnosed in general condition. Conclusion BNP level is an effective way to identify cardiac and non-cardiac dyspnea.

关 键 词：B型利钠肽 呼吸困难 心力衰竭 急性 诊断 

分 类 号：R446.1[医药卫生—诊断学]