异常孕产史夫妇染色体的分析  

Chromosomal analysis in the cases with the history of abnormal pregnancy.

作　　者：刘波[1] 李山[1] 秦雪[1] 莫武宁[1] 薛小霞[1] 陈以文[1] 

机构地区：[1]广西医科大学第一附属医院临床医学实验中心,南宁530021

出　　处：《中国优生与遗传杂志》2005年第4期45-46,共2页Chinese Journal of Birth Health & Heredity

基　　金：广西卫生厅科研基金项目 (Z2 0 0 3 0 2 5 ) ;美国增进人类健康 (PSBH)基金资助项目 (2 0 0 3 0 6)

摘　　要：目的　探讨异常孕产史与细胞遗传学的关系。方法　收集异常孕产史夫妇外周血,对外周血淋巴细胞进行培养、制片、胰酶消化、G显带、分析。结果　分析2 2 9对异常孕产史夫妇的染色体核型,发现异常34例,异常发生率为7.4 2 % ,其中平衡易位6例,检出率为1.31% (占异常总数的17.6 5 % ) ,罗伯逊易位1例,检出率为0 .2 2 % (占异常总数的2 .94 % ) ,复杂易位1例,检出率为0 .2 2 % (占异常总数的2 .94 % ) ,臂间倒位8例,检出率为1.75 % (占异常总数的2 3.5 3% ) ,其它异常核型18例,检出率为3.93% (占异常总数的5 2 .94 % )。结论　染色体异常是导致异常孕产史的重要因素之一。Objective: To investigate the relationship between abnormal pregnancy and cytogenetics. Methods: The peripheral blood in 229 couples with abnormal pregnancy were collected. The chromosomal karyotypes of peripheral lymphocytes in 229 couples with abnormal pregnancy were analyzed using G-banding after lymphocytes were treated with trypsin. Results: There were 34 abnormal karyotypes in 229 couples with abnormal pregnancy. The rate of abnormal karyotypes was 7.42%. Among the 34 cases of abnormal karyotypes, 6 cases of balanced translocation were discovered, it was 1.31% in all cases(17.65% in abnormal karyotypes); 1 case of robertsonian translocation was discovered, it was 0.22% in all cases(2.94% in abnormal karyotypes); 1 case of complex translocation was discovered, it was 0.22% in all cases(2.94% in abnormal karyotypes); 8 cases of pericentric inversion were discovered, it was 1.75% in all cases(23.53% in abnormal karyotypes); 18 cases of other abnormal karyotypes were discovered, it was 3.93% in all cases(52.94% in all abnormal karyotypes). Conclusion: The abnormality of chromosome is one of reasons of abnormal pregnancy.

关 键 词：异常孕产史 异常核型 染色体 

分 类 号：R714.2[医药卫生—妇产科学]