Solid-phase Synthesis of PNA Monomer by Ugi Four-component Condensation Reaction  

作　　者：WenHaoWANG XiaoMinZOU XinZHANG YiQiuFU PingXU 

机构地区：[1]DepartmentofMedicinalChemistry,SchoolofPharmaceuticalSciences,PekingUniversity,Beijing100083

出　　处：《Chinese Chemical Letters》2005年第5期585-588,共4页中国化学快报（英文版）

基　　金：This work was supposed by the National Basic Research Program(973 Program)from the Ministry of Science and Technology of China(G1998051114);the National Natural Science Foundation of China(20272004)

摘　　要：Peptide nucleic acids (PNA) oligomers were synthesized in most cases by peptide synthesis from N-protected monomers. In this work a new method of obtaining PNA monomer by Ugi four-component condensation reaction was tested by solid-phase synthesis. The Fmoc protected PNA monomer was build up with thymin-1-yl acetic acid, 3-methylbutyl aldehyde, Fmoc protected aminoethyl isocyanide and Gly-Wang resin.

关 键 词：Peptide nucleic acids (PNA) Ugi four-component condensation reaction (U-4CR) Solid-phase synthesis Isocyanide. 

分 类 号：O626.413[理学—有机化学]