Synthesis of 24-Methylene-cholest-5-ene-7-oxo-3β,19-diacetate  

作　　者：WeiGangLU CuiXianZHANG JingYuSU LongMeiZENG 

机构地区：[1]SchoolofChemistryandChemicalEngineering,SunYat-SenUniversity,Guangzhou510275

出　　处：《Chinese Chemical Letters》2005年第5期604-606,共3页中国化学快报（英文版）

基　　金：We are grateful to the National Natural Science Foundation of China (No. 29932030);the NationalHigh Technology Development Project (No. 2001AA624030);the Natural Science Foundationof Guangdong Province (No. 04300569) for financial support for this work.

摘　　要：24-Methylenecholest-5-ene-7-oxo-3β,19-diacetate 5 was synthesized starting from stigmasterol via twelve step reactions in 4.1% overall yield. It can be served as a key intermediate for the synthesis of 24-methylenecholest-5-ene-3β,7β,19-triol 1, a naturally occuring polyhydroxylated sterol with potential biological activity.

关 键 词：24-Methylene-cholest-5-ene-3β 7β 19-triol synthesis allylic oxidation PCC/Al2O3. 

分 类 号：O623.624[理学—有机化学]