流行性出血热病毒Z_（20）株引起的细胞融合及其形态特点  

Cell Fusion Induced by Strain Z_(20) of Epidemic Hemorrhagic Fever Virus and Its Morphologic Characteristics

作　　者：叶克龙 田美英[1] 周联娣[1] 李永良[1] 徐志一[1] 

机构地区：[1]上海医科大学流行病学教研室

出　　处：《中国公共卫生学报》1994年第3期129-131,共3页

基　　金：上海市卫生局资助

摘　　要：实验结果表明：流行性出血热（ＥＨＦ）病毒Ｚ２０株，在３７℃经ｐＨ６．０细胞融合液处理，可引起细胞融合现象。随感染ＥＨＦ病毒的细胞培养天数延长，细胞融合灶逐渐增多。细胞融合的形态特点表现为：首先细胞之间趋向紧密，伴有细胞膜消失，接着核大量聚集，进而变形，最后出现收缩形成融合灶。Epidemic hemorrbagic fever virus.strain Z20 caused cell fusion after exposing to acid environment(pH6. 0). As the infected cells(Vero-E6 cell line) were cultured longer. number of cell fusion foci increased. Morphologicall cell fusion showed that infected cells adhere each other, with disappearance of cell membrance and cluster of nuclei;the muclei became multiform and giant in feature;and finally a complete fusion foci estableshed.

关 键 词：流行性出血热 细胞融合 形态 

分 类 号：R373.32[医药卫生—病原生物学]