自来水有机浓集物对大鼠肝脏DNA损伤的实验研究  

An Experimental Study of Injurious Effect of Organics Concentrates the Tap water on Rat Liver DNA

作　　者：刘世良[1] 何尚浦[1] 张亚飞[1] 施侣元[1] 徐代根[1] 张惠娟[1] 

机构地区：[1]同济医科大学流行病学教研室,同济医科大学工业毒理研究室

出　　处：《中国公共卫生学报》1994年第4期222-224,共3页

摘　　要：应用ＤＮＡ碱解链试验检测东湖和长江源水自来水有机浓集物遗传毒性。结果表明：东湖源水自来水全部剂量组和长江源水自来水高剂量组对ＤＮＡ有损伤，且具有剂量反应关系（Ｐ＜０．０１或Ｐ＜０．０５）。该试验方法的应用有助于揭示饮用水有机污染物的体内代谢过程和致突变机理。The study was made to measure the genotoxicity of the organic concentrates in the tap water from the Dong Lake and the Yangtse River by using DNA alkline unwinding assay.There were male 40 rats classified into twO experimental groups,one positive gtoup and one negative group in the experiment.The resuits showed that there were evident DNA damage in all dosages of the tap water from the Dong Lake and in the highest dosage from the Yangtse River,and there was postive dose-effect relationship(P<0.01 or P<0.05).The application of this assay would contribute to explain the metabolic process and mutagenic mechanism of the organic pollutants in drinking water in the human body.

关 键 词：饮用水 DNA 损伤 致突变 

分 类 号：R994.6[医药卫生—毒理学]